Article
Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity.
The Journal of rheumatology - 1 Mar 2009
Fisher Mark C, Cronstein Bruce N
Abstract excerpt
OBJECTIVE: Methotrexate (MTX) is an effective therapy for rheumatoid arthritis (RA) but it is also associated with toxicity. Pharmacogenetics is the systematic evaluation of the role of genetic differences in the efficacy and toxicity of therapeutic interventions. Because the results of small pharmacogenetic studies are often misleading, we undertook a metaanalysis of published studies to determine the role of...
Topics
- Enzyme Inhibitors
- Genetic Predisposition to Disease
- Humans
- Methotrexate
- Methylenetetrahydrofolate Reductase (NADPH2)
- Odds Ratio
- Polymorphism, Single Nucleotide