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Article

Methotrexate: Implications of pharmacogenetics in the treatment of patients with Rheumatoid Arthritis.

ARP rheumatology - 1 Oct 2022

Torres Rita Pinheiro, Santos Fernando Pimentel, Branco Jaime Cunha

Abstract excerpt

BACKGROUND: Methotrexate (MTX) is an anti-folate drug with anti-proliferative and anti-inflammatory effects. MTX proved to be the most highly effective, fast-acting disease modifying anti-rheumatic drug (DMARD), being widely used for the treatment of rheumatoid arthritis (RA). This review aims to describe the main genetic variants identified concerning proteins that play a role in methotrexate's kinetics and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35724450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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