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Article

The impact of folate pathway variants on the outcome of methotrexate therapy in rheumatoid arthritis patients.

Clinical rheumatology - 1 Mar 2024

Nomair Azhar M, Abdelati Abeer, Dwedar Fatma I, Elnemr Rehab, Kamel Yasmine N, Nomeir Hanan M

Abstract excerpt

BACKGROUND: There are currently no validated criteria that entirely explain or predict response to methotrexate (MTX) treatment in rheumatoid arthritis (RA). We tried to identify the connection between three variants (RFC1 G80A (rs1051266), TYMS 2R/3R (rs34743033), and ATIC C347G (rs2372536)) in the folate pathway of MTX metabolism and the response to MTX monotherapy in a cohort of RA cases. METHODS: A...

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Share to Acute Lymphoblastic Leukemia research
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Identifiers

PMID: 38311638
DOI: 10.1007/s10067-024-06892-w
PMCID: PMC10876746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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