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Article

Identification of cytokines that might enhance the promoter activity of HLA-B27.

The Journal of rheumatology - 1 May 2008

Zhao Like, Fong Yoly, Granfors Kaisa, Gu Jieruo, Yu David

Abstract excerpt

OBJECTIVE: Although the mechanism by which HLA-B27 induces ankylosing spondylitis is unclear, a minimum threshold of transcription is essential, a process controlled at the promoter. Our aim was to scan the effect of a panel of cytokines on the promoter of the HLA-B27 gene over serial timepoints. METHODS: The promoter region of B*2705 gene was cloned into a luciferase reporter, stably transfected into HeLa cells,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18381783

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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