Article
Childhood-onset restless legs syndrome: clinical and genetic features of 22 families.
Movement disorders : official journal of the Movement Disorder Society - 15 Jun 2008
Muhle Hiltrud, Neumann Anja, Lohmann-Hedrich Katja, Lohnau Thora, Lu Yang, Winkler Susen, Waltz Stephan, Fischenbeck Anke, Kramer Patricia L, Klein Christine, Stephani Ulrich
Abstract excerpt
Restless legs syndrome (RLS) is a sensory-motor disorder that is underdiagnosed in children and often misclassified as attention deficit hyperactivity disorder. Five different gene loci (RLS1-5) and three susceptibility loci have been identified in adult-onset RLS. We included 23 children with RLS (age at onset < or =14 years) from 22 families. In 14 families, we performed linkage and genotype analyses. Of the 23...
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