Article
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice.
The Journal of cell biology - 7 Apr 2008
Espada Jesús, Varela Ignacio, Flores Ignacio, Ugalde Alejandro P, Cadiñanos Juan, Pendás Alberto M, Stewart Colin L, Tryggvason Karl, Blasco María A, Freije José M P, López-Otín Carlos
Abstract excerpt
Nuclear lamina alterations occur in physiological aging and in premature aging syndromes. Because aging is also associated with abnormal stem cell homeostasis, we hypothesize that nuclear envelope alterations could have an important impact on stem cell compartments. To evaluate this hypothesis, we examined the number and functional competence of stem cells in Zmpste24-null progeroid mice, which exhibit nuclear...
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