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Article

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

Nature - 22 Sept 2005

Varela Ignacio, Cadiñanos Juan, Pendás Alberto M, Gutiérrez-Fernández Ana, Folgueras Alicia R, Sánchez Luis M, Zhou Zhongjun, Rodríguez Francisco J, Stewart Colin L, Vega José A, Tryggvason Karl, Freije José M P, López-Otín Carlos

Abstract excerpt

Zmpste24 (also called FACE-1) is a metalloproteinase involved in the maturation of lamin A (Lmna), an essential component of the nuclear envelope. Both Zmpste24- and Lmna-deficient mice exhibit profound nuclear architecture abnormalities and multiple histopathological defects that phenocopy an ac...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16079796
DOI: 10.1038/nature04019

Genes

LMNA
ZMPSTE24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16079796-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.PMID 16079796Read ↗

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New ZMPSTE24 (FACE1) mutations in patients affected with restrictive dermopathy or related progeroid syndromes and mutation update.Semantic proximity Read ↗

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