Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jan 2007

Halaschek-Wiener Julius, Brooks-Wilson Angela

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, fatal genetic disorder that is characterized by segmental accelerated aging. The major causal mutation associated with HGPS triggers abnormal messenger RNA splicing of the lamin A gene leading to changes in the nuclear architecture. To date,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Apoptosis
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lamin Type A

Share to Progeria

Share to Regeneration

Share to RNA, Messenger

Share to Stem Cells

Source

Identifiers

PMID: 17301031
DOI: 10.1093/gerona/62.1.3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17301031-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome.PMID 17301031Read ↗

Molecular insights into the premature aging disease progeria.Semantic proximity Read ↗

Stem cell depletion in Hutchinson-Gilford progeria syndrome.Semantic proximity Read ↗

Unraveling the mysteries of aging through a Hutchinson-Gilford progeria syndrome model.Semantic proximity Read ↗

Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome.Semantic proximity Read ↗

Towards delineating the chain of events that cause premature senescence in the accelerated aging syndrome Hutchinson-Gilford progeria (HGPS).Semantic proximity Read ↗

Premature aging syndromes: From patients to mechanism.Semantic proximity Read ↗

Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery.Semantic proximity Read ↗

Hereditary Syndromes With Signs of Premature AgingSemantic proximity Read ↗

Evidence for the involvement of lamins in aging.Semantic proximity Read ↗

Hutchinson-Gilford Progeria Syndrome: A Literature ReviewSemantic proximity Read ↗

Hutchinson-Gilford progeria syndrome through the lens of transcription.Semantic proximity Read ↗

Transcriptional profiling of Hutchinson-Gilford Progeria syndrome fibroblasts reveals deficits in mesenchymal stem cell commitment to differentiation related to early events in endochondral ossificationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.