Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1.

The Journal of investigative dermatology - 1 Dec 2012

Li Ji, Jiang Ting-Xin, Hughes Michael W, Wu Ping, Yu Juehua, Widelitz Randall B, Fan Guoping, Chuong Cheng-Ming

Abstract excerpt

To examine the roles of epigenetic modulation on hair follicle regeneration, we generated mice with a K14-Cre-mediated loss of DNA methyltransferase 1 (DNMT1). The mutant shows an uneven epidermal thickness and alterations in hair follicle size. When formed, hair follicle architecture and differentiation appear normal. Hair subtypes exist but hair fibers are shorter and thinner. Hair numbers appear normal at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adult Stem Cells
Share to Alopecia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferase 1

Share to DNA (Cytosine-5-)-Methyltransferases

Share to Epidermis

Share to Hair Follicle

Share to Homeostasis

Source

Open in PubMed Open full text

Identifiers

PMID: 22763785
DOI: 10.1038/jid.2012.206
PMCID: PMC3465630

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1.PMID 22763785Read ↗

Disruption of Smad4 in mouse epidermis leads to depletion of follicle stem cells.Semantic proximity Read ↗

Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular declineSemantic proximity Read ↗

Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile PhenotypeSemantic proximity Read ↗

Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermisSemantic proximity Read ↗

Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling.Semantic proximity Read ↗

β-Catenin Signaling Evokes Hair Follicle Senescence by Accelerating the Differentiation of Hair Follicle Mesenchymal ProgenitorsSemantic proximity Read ↗

Differential response of epithelial stem cell populations in hair follicles to TGF-β signaling.Semantic proximity Read ↗

Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin.Semantic proximity Read ↗

Gsdma3 mutation causes bulge stem cell depletion and alopecia mediated by skin inflammation.Semantic proximity Read ↗

Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound HealingSemantic proximity Read ↗

Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis.Semantic proximity Read ↗

Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profileSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.