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Article

Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1.

The Journal of investigative dermatology - 1 Dec 2012

Li Ji, Jiang Ting-Xin, Hughes Michael W, Wu Ping, Yu Juehua, Widelitz Randall B, Fan Guoping, Chuong Cheng-Ming

Abstract excerpt

To examine the roles of epigenetic modulation on hair follicle regeneration, we generated mice with a K14-Cre-mediated loss of DNA methyltransferase 1 (DNMT1). The mutant shows an uneven epidermal thickness and alterations in hair follicle size. When formed, hair follicle architecture and differe...

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Source

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Identifiers

PMID: 22763785
DOI: 10.1038/jid.2012.206
PMCID: PMC3465630

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22763785-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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