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Article

Mutations in the retinoblastoma-related gene RB2/p130 in adult T-cell leukaemia/lymphoma.

Leukemia & lymphoma - 1 Apr 2003

Takeuchi Seisho, Takeuchi Naoko, Tsukasaki Kunihiro, Fermin Anthony C, De Vas Sven, Seo Hiromi, Koeffler H Phillip

Abstract excerpt

The retinoblastoma (Rb) family consists of the tumor suppressor Rb/p105 and related proteins p107 and Rb2/p130. Although the involvement of the RB/p105 gene in Adult T-cell leukaemia/lymphoma (ATL) has been studied, no mutational data is reported regarding the RB2/p130 gene in ATL. We screened fo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12769348
DOI: 10.1080/1042819031000063480

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12769348-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Mutations in the retinoblastoma-related gene RB2/p130 in adult T-cell leukaemia/lymphoma.PMID 12769348Read ↗

Genetic alterations disrupting the nuclear localization of the retinoblastoma-related gene RB2/p130 in human tumor cell lines and primary tumors.Semantic proximity Read ↗

Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer.Semantic proximity Read ↗

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Expression of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: Implications for disease pathogenesisSemantic proximity Read ↗

Genetic alterations at the nuclear localization signal of the RB2/p130 gene occur in lymphoid tumor but not in osteosarcoma cell lines.Semantic proximity Read ↗

Role of tumor suppressor genes in the development of adult T cell leukemia/lymphoma (ATLL).Semantic proximity Read ↗

High incidence of allelic loss at 16q12.2 region spanning RBL2/p130 gene in retinoblastoma.Semantic proximity Read ↗

Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas.Semantic proximity Read ↗

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