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Article

Transglutaminase-Mediated Activation of Nuclear Transcription Factor-&#954;B in Cancer Cells: A New Therapeutic Opportunity

28 Aug 2007

Abstract excerpt

The nuclear factor kappaB (NF-kappaB) plays an important role in tumorigenesis by affecting processes such as tumor initiation, promotion, growth, and metastasis. NF-kappaB induces the expression of genes that are known to confer resistance to apoptosis. Therefore, its activation has been associated with the development of chemo- and radiation resistance in cancer cells. NF-kappaB is constitutively activated in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17896921
DOI: 10.2174/156800907781662275

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