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Article

Insulin-Producing Cells Differentiated from Human Bone Marrow Mesenchymal Stem Cells In Vitro Ameliorate Streptozotocin-Induced Diabetic Hyperglycemia.

PloS one - 1 Jan 2016

Xin Ying, Jiang Xin, Wang Yishu, Su Xuejin, Sun Meiyu, Zhang Lihong, Tan Yi, Wintergerst Kupper A, Li Yan, Li Yulin

Abstract excerpt

BACKGROUND: The two major obstacles in the successful transplantation of islets for diabetes treatment are inadequate supply of insulin-producing tissue and immune rejection. Induction of the differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) into insulin-producing cells (IPCs) for autologous transplantation may alleviate those limitations. METHODS: hMSCs were isolated and induced to...

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Identifiers

PMID: 26756576
DOI: 10.1371/journal.pone.0145838
PMCID: PMC4710504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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