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Article

Primary orthotopic glioma xenografts recapitulate infiltrative growth and isocitrate dehydrogenase I mutation.

Journal of visualized experiments : JoVE - 14 Jan 2014

Valadez J Geraldo, Sarangi Anuraag, Lundberg Christopher J, Cooper Michael K

Abstract excerpt

Malignant gliomas constitute a heterogeneous group of highly infiltrative glial neoplasms with distinct clinical and molecular features. Primary orthotopic xenografts recapitulate the histopathological and molecular features of malignant glioma subtypes in preclinical animal models. To model WHO grades III and IV malignant gliomas in transplantation assays, human tumor cells are xenografted into an orthotopic...

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PMID: 24458098
DOI: 10.3791/50865
PMCID: PMC4396882

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