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Article

Generation of Glioblastoma Patient-Derived Intracranial Xenografts for Preclinical Studies

20 Jul 2020

Abstract excerpt

Glioblastoma multiforme (GBM) is the most malignant primary brain cancer affecting adults. Therapeutic options for GBM have remained the same for over a decade with no significant improvement. Many therapies that are successful in culture have failed in patients, likely due to the complex microenvironment in the brain, which has yet to be reproduced in any culture model. Furthermore, the high passage number of...

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PMID: 32698368
DOI: 10.3390/ijms21145113

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