Mammalian Target of Rapamycin (mTOR) is Activated in Cutaneous Vascular Malformations <i>in Vivo</i>

Abstract excerpt

BACKGROUND: Vascular malformation signaling pathways are the least understood out of all cutaneous endothelial lesions. The overexpression of Akt is known to cause vascular malformations in endothelial cells of mice. Since there are no Akt inhibitors approved for clinical use, we examined phosphorylated S6 expression, a downstream target of Akt. Phosphorylated S6 indicates potential sensitivity to rapamycin....

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