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Article

Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia.

Nature - 22 May 2003

Jumaa Hassan, Bossaller Lukas, Portugal Karina, Storch Bettina, Lotz Michael, Flemming Alexandra, Schrappe Martin, Postila Ville, Riikonen Pekka, Pelkonen Jukka, Niemeyer Charlotte M, Reth Michael

Abstract excerpt

Acute lymphoblastic leukaemia (ALL) is the commonest form of childhood malignancy, and most cases arise from B-cell clones arrested at the pre-B-cell stage of differentiation. The molecular events that arrest pre-B-cell differentiation in the leukaemic pre-B cells have not been well characterized. Here we show that the differentiation regulator SLP-65 (an adaptor protein also called BLNK or BASH) inhibits...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12761551
DOI: 10.1038/nature01608

Genes

BLNK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia.PMID 12761551Read ↗

C/EBPβ induces B-cell acute lymphoblastic leukemia and cooperates with BLNK mutations.Semantic proximity Read ↗

The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.Semantic proximity Read ↗

SLP-65 signal transduction requires Src homology 2 domain-mediated membrane anchoring and a kinase-independent adaptor function of Syk.Semantic proximity Read ↗

A leucine zipper in the N terminus confers membrane association to SLP-65.Semantic proximity Read ↗

The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells.Semantic proximity Read ↗

An Essential Role for BLNK in Human B Cell DevelopmentSemantic proximity Read ↗

Enteroviral Infection in a Patient with BLNK Adaptor Protein Deficiency.Semantic proximity Read ↗

Highly restricted usage of Ig H chain VH14 family gene segments in Slp65-deficient pre-B cell leukemia in mice.Semantic proximity Read ↗

The BLNK adaptor protein has a nonredundant role in human B-cell differentiation.Semantic proximity Read ↗

Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.Semantic proximity Read ↗

The N terminus of the non-T cell activation linker (NTAL) confers inhibitory effects on pre-B cell differentiation.Semantic proximity Read ↗

Cutting edge: B cell linker protein is dispensable for the allelic exclusion of immunoglobulin heavy chain locus but required for the persistence of CD5+ B cells.Semantic proximity Read ↗

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