Article
Unexpected roles for UPF1 in HIV-1 RNA metabolism and translation.
RNA (New York, N.Y.) - 1 May 2008
Ajamian Lara, Abrahamyan Levon, Milev Miroslav, Ivanov Pavel V, Kulozik Andreas E, Gehring Niels H, Mouland Andrew J
Abstract excerpt
The HIV-1 ribonucleoprotein (RNP) contains the major structural protein, pr55(Gag), viral genomic RNA, as well as the host protein, Staufen1. In this report, we show that the nonsense-mediated decay (NMD) factor UPF1 is also a component of the HIV-1 RNP. We investigated the role of UPF1 in HIV-1-expressing cells. Depletion of UPF1 by siRNA resulted in a dramatic reduction in steady-state HIV-1 RNA and pr55(Gag)....
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