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Article

Elucidation of the Mechanism of Host NMD Suppression by HTLV-1 Rex: Dissection of Rex to Identify the NMD Inhibitory Domain.

Viruses - 9 Feb 2022

Nakano Kazumi, Karasawa Nobuaki, Hashizume Masaaki, Tanaka Yuetsu, Ohsugi Takeo, Uchimaru Kaoru, Watanabe Toshiki

Abstract excerpt

The human retrovirus human T-cell leukemia virus type I (HTLV-1) infects human T cells by vertical transmission from mother to child through breast milk or horizontal transmission through blood transfusion or sexual contact. Approximately 5% of infected individuals develop adult T-cell leukemia/lymphoma (ATL) with a poor prognosis, while 95% of infected individuals remain asymptomatic for the rest of their lives,...

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Identifiers

PMID: 35215946
DOI: 10.3390/v14020344
PMCID: PMC8875924

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