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Article

Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages

7 Feb 2019

Abstract excerpt

BACKGROUND: Mammalian cells harbour RNA quality control and degradative machineries such as nonsense-mediated mRNA decay that target cellular mRNAs for clearance from the cell to avoid aberrant gene expression. The role of the host mRNA decay pathways in macrophages in the context of human immunodeficiency virus type 1 (HIV-1) infection is yet to be elucidated. Macrophages are directly infected by HIV-1, mediate...

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PMID: 30732620
DOI: 10.1186/s12977-019-0465-2

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