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Article

The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development.

Developmental biology - 1 May 2008

Gage Philip J, Qian Min, Wu Dianqing, Rosenberg Kevin I

Abstract excerpt

Local control of cell signaling activity and integration of inputs from multiple signaling pathways are central for normal development but the underlying mechanisms remain poorly understood. Here we show that Dkk2, encoding an antagonist of canonical Wnt signaling, is an essential downstream targ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18367164
DOI: 10.1016/j.ydbio.2008.02.030
PMCID: PMC2387126

Genes

PITX2
DKK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18367164-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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