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Article

Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium.

Development (Cambridge, England) - 1 Jun 2006

Mukhopadhyay Mahua, Gorivodsky Marat, Shtrom Svetlana, Grinberg Alexander, Niehrs Christoph, Morasso Maria I, Westphal Heiner

Abstract excerpt

The Dkk family of secreted cysteine-rich proteins regulates Wnt/beta-catenin signaling by interacting with the Wnt co-receptor Lrp5/6. Here, we show that Dkk2-mediated repression of the Wnt/beta-catenin pathway is essential to promote differentiation of the corneal epithelial progenitor cells into a non-keratinizing stratified epithelium. Complete transformation of the corneal epithelium into a stratified...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16672341
DOI: 10.1242/dev.02381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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