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Article

Head formation: OTX2 regulates Dkk1 and Lhx1 activity in the anterior mesendoderm.

Development (Cambridge, England) - 1 Oct 2014

Ip Chi Kin, Fossat Nicolas, Jones Vanessa, Lamonerie Thomas, Tam Patrick P L

Abstract excerpt

The Otx2 gene encodes a paired-type homeobox transcription factor that is essential for the induction and the patterning of the anterior structures in the mouse embryo. Otx2 knockout embryos fail to form a head. Whereas previous studies have shown that Otx2 is required in the anterior visceral endoderm and the anterior neuroectoderm for head formation, its role in the anterior mesendoderm (AME) has not been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25231759
DOI: 10.1242/dev.114900

Genes

OTX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Head formation: OTX2 regulates Dkk1 and Lhx1 activity in the anterior mesendoderm.PMID 25231759Read ↗

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Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation.Semantic proximity Read ↗

OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.Semantic proximity Read ↗

The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development.Semantic proximity Read ↗

Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm.Semantic proximity Read ↗

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.Semantic proximity Read ↗

Mouse Otx2 functions in the formation and patterning of rostral head.Semantic proximity Read ↗

belladonna/(Ihx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain.Semantic proximity Read ↗

Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endodermSemantic proximity Read ↗

Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo.Semantic proximity Read ↗

Functional equivalency between Otx2 and Otx1 in development of the rostral head.Semantic proximity Read ↗

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