Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.

Development (Cambridge, England) - 1 Dec 2009

Yun Sanghee, Saijoh Yukio, Hirokawa Karla E, Kopinke Daniel, Murtaugh L Charles, Monuki Edwin S, Levine Edward M

Abstract excerpt

A crucial step in eye organogenesis is the transition of the optic vesicle into the optic cup. Several transcription factors and extracellular signals mediate this transition, but whether a single factor links them into a common genetic network is unclear. Here, we provide evidence that the LIM homeobox gene Lhx2, which is expressed in the optic neuroepithelium, fulfils such a role. In Lhx2(-/-) mouse embryos,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique, Direct

Share to In Situ Hybridization

Share to LIM-Homeodomain Proteins

Share to Organ Culture Techniques

Share to Organogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 19906857
DOI: 10.1242/dev.041202
PMCID: PMC2778739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.PMID 19906857Read ↗

LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis.Semantic proximity Read ↗

A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development.Semantic proximity Read ↗

Loss of Tbx2 delays optic vesicle invagination leading to small optic cups.Semantic proximity Read ↗

Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells.Semantic proximity Read ↗

Dual role for LIM-homeodomain gene Lhx2 in the formation of the lateral olfactory tract.Semantic proximity Read ↗

Deletion of OTX2 in neural ectoderm delays anterior pituitary development.Semantic proximity Read ↗

Molecular and developmental mechanisms of anterior segment dysgenesis.Semantic proximity Read ↗

Loss of Axin2 Causes Ocular Defects During Mouse Eye Development.Semantic proximity Read ↗

Relationship between neural crest cell specification and rare ocular diseases.Semantic proximity Read ↗

belladonna/(Ihx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain.Semantic proximity Read ↗

aldh7a1 regulates eye and limb development in zebrafish.Semantic proximity Read ↗

The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.