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Article

Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions.

Biochemical pharmacology - 15 Nov 2016

Banerjee Mayukh, Marensi Vanessa, Conseil Gwenaëlle, Le X Chris, Cole Susan P C, Leslie Elaine M

Abstract excerpt

Broad inter-individual variation exists in susceptibility to arsenic-induced tumours, likely involving differences in the ability of individuals to eliminate this metalloid. We recently identified human multidrug resistance protein 4 (MRP4/ABCC4) as a novel pathway for the cellular export of dimethylarsinic acid (DMAV), the major urinary arsenic metabolite in humans, and the diglutathione conjugate of the highly...

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Identifiers

PMID: 27659809
DOI: 10.1016/j.bcp.2016.09.016

Genes

ABCC4

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Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions.PMID 27659809Read ↗

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