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Article

Interferon and ribavirin therapy does not select for resistance mutations in hepatitis C virus polymerase.

Journal of viral hepatitis - 1 Aug 2008

Ward C L, Dev A, Rigby S, Symonds W T, Patel K, Zekry A, Pawlotsky J-M, McHutchison J G

Abstract excerpt

Ribavirin has a minor and transient effect on hepatitis C virus (HCV) replication and has been suggested to select a novel mutation, F415Y, in the RNA-dependent RNA polymerase of subtype 1a viruses. Twenty-nine patients with chronic hepatitis C (subtyped by INNO LiPA as 1a, 17; 1b, 11; 1a/1b, 1) who were nonresponders to interferon-based therapies were identified retrospectively and screened at Baseline, week 24...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18363671
DOI: 10.1111/j.1365-2893.2008.00980.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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