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Article

Mechanisms of Disease: ryanodine receptor defects in heart failure and fatal arrhythmia.

Nature clinical practice. Cardiovascular medicine - 1 Jan 2006

Yano Masafumi, Yamamoto Takeshi, Ikeda Yasuhiro, Matsuzaki Masunori

Abstract excerpt

Abnormal regulation of intracellular Ca(2+) by sarcoplasmic reticulum plays a part in the mechanism underlying contractile and relaxation dysfunction in heart failure (HF). The protein-kinase-A-mediated hyperphosphorylation of ryanodine receptors in the sarcoplasmic reticulum has been shown to cause the dissociation of FKBP12.6 (also known as calstabin-2) from ryanodine receptors in HF. In addition, several...

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Source

Identifiers

PMID: 16391617
DOI: 10.1038/ncpcardio0419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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