Article
Assessment of mitochondrial DNA polymorphisms in salt-sensitive hypertension in Dahl salt-sensitive rats.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jan 2008
Chen Chu-Shih, Hiura Yumiko, Shen Chun-Shen, Iwai Naoharu
Abstract excerpt
The Dahl salt-sensitive (DS) rat is the most prevalently used animal model of salt-sensitive hypertension. The purpose of the present study was to test the hypothesis that mitochondrial DNA (mtDNA) polymorphisms influence blood pressure in DS rats. We produced two strains of female F1 rats, one from female DS and male Lewis rats (DL) and the other from Lewis female and DS male rats (LD). These two strains had the...
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