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Article

Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular function.

Journal of biomechanics - 5 Feb 2015

Golob Mark J, Tian Lian, Wang Zhijie, Zimmerman Todd A, Caneba Christine A, Hacker Timothy A, Song Guoqing, Chesler Naomi C

Abstract excerpt

Aging is associated with conduit artery stiffening that is a risk factor for and can precede hypertension and ventricular dysfunction. Increases in mitochondria DNA (mtDNA) frequency have been correlated with aging. Mice with a mutation in the encoding domain (D257A) of a proof-reading deficient version of mtDNA polymerase-γ (POLG) have musculoskeletal features of premature aging and a shortened lifespan....

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Source

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Identifiers

PMID: 25582357
DOI: 10.1016/j.jbiomech.2014.12.044
PMCID: PMC4306604

Genes

POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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