Article
The alpha1 Na,K-ATPase gene is a susceptibility hypertension gene in the Dahl salt-sensitiveHSD rat.
The Journal of clinical investigation - 15 Sept 1998
Herrera V L, Xie H X, Lopez L V, Schork N J, Ruiz-Opazo N
Abstract excerpt
Despite the prevalence of essential hypertension, its underlying genetic basis has not been elucidated due to the complexities of its determinants. To identify a hypertension susceptibility gene, we used an approach that integrates molecular, transgenic, and genetic analysis using Dahl salt-sensi...
Topics
- Animals
- Animals, Genetically Modified
- Blood Pressure Determination
- Chromosome Mapping
- Crosses, Genetic
- Dextrans
- Disease Susceptibility
- Drug Resistance
- Genetic Linkage
- Genotype
- Heterozygote
- Homozygote
- Hypertension
- Hypertension, Renal
- Phenotype
- Rats
- Sodium Chloride
- Sodium-Potassium-Exchanging ATPase