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Article

Characterization of the chicken β-globin insulator

21 Jan 1997

Abstract excerpt

Insulators, first identified in Drosophila, are DNA sequence elements that shield a promoter from nearby regulatory elements. We have previously reported that a DNA sequence at the 5' end of the chicken beta-globin locus can function as an insulator. It is capable of shielding a reporter gene from the activating effects of a nearby mouse beta-globin locus control region element in the human erythroleukemic cell...

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Identifiers

PMID: 9012826
DOI: 10.1073/pnas.94.2.575

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the chicken β-globin insulatorPMID 9012826Read ↗

Chicken beta-globin insulator overcomes variegation of transgenes in Xenopus embryos.Semantic proximity Read ↗

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators.Semantic proximity Read ↗

Optimized Lentiviral Vector Design Improves Titer and Transgene Expression of Vectors Containing the Chicken β-Globin Locus HS4 Insulator ElementSemantic proximity Read ↗

Human β-Globin Locus Control Region HS5Contains CTCF- and Developmental Stage-Dependent Enhancer-BlockingActivity in ErythroidCellsSemantic proximity Read ↗

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in DrosophilaSemantic proximity Read ↗

GATA-1 modulates the chromatin structure and activity of the chicken alpha-globin 3' enhancer.Semantic proximity Read ↗

Conserved E Boxes Function as Part of the Enhancer in Hypersensitive Site 2 of the β-Globin Locus Control RegionSemantic proximity Read ↗

Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.Semantic proximity Read ↗

Insulators are fundamental components of the eukaryotic genomes.Semantic proximity Read ↗

Improved Human β-globin Expression from Self-inactivating Lentiviral Vectors Carrying the Chicken Hypersensitive Site-4 (cHS4) Insulator ElementSemantic proximity Read ↗

Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes.Semantic proximity Read ↗

An insulator with barrier-element activity promotes α-spectrin gene expression in erythroid cellsSemantic proximity Read ↗

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