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Article

Increased ADAM17 mRNA expression and activity is associated with atherosclerosis resistance in LDL-receptor deficient mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2008

Holdt Lesca M, Thiery Joachim, Breslow Jan L, Teupser Daniel

Abstract excerpt

BACKGROUND: We have previously identified an atherosclerosis quantitative trait locus (QTL) on mouse chromosome (Chr) 12 in an F2-intercross of atherosclerosis-resistant FVB and atherosclerosis-susceptible C57BL/6 (B6) mice on the LDL-receptor deficient (LDL-/-) background. The aim of the present study was to identify potentially causative genes at this locus. METHODS AND RESULTS: Expression QTL (eQTL) analysis...

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Source

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Identifiers

PMID: 18356551
DOI: 10.1161/ATVBAHA.108.165654
PMCID: PMC2789234

Genes

ADAM17
LDLR
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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