Article
Power and SNP tagging in whole mitochondrial genome association studies.
Genome research - 1 Jun 2008
McRae Allan F, Byrne Enda M, Zhao Zhen Zhen, Montgomery Grant W, Visscher Peter M
Abstract excerpt
The application of genetic association studies to detect mitochondrial variants responsible for phenotypic variation has recently been demonstrated. However, the only power estimates currently available are based on the use of mitochondrial haplogroups, which can only tag a small fraction of the common variation in the mitochondrial genome. Here, power estimates are derived for a SNP-based study design for both...
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