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Article

A simulation study investigating power estimates in phenome-wide association studies.

BMC bioinformatics - 4 Apr 2018

Verma Anurag, Bradford Yuki, Dudek Scott, Lucas Anastasia M, Verma Shefali S, Pendergrass Sarah A, Ritchie Marylyn D

Abstract excerpt

BACKGROUND: Phenome-wide association studies (PheWAS) are a high-throughput approach to evaluate comprehensive associations between genetic variants and a wide range of phenotypic measures. PheWAS has varying sample sizes for quantitative traits, and variable numbers of cases and controls for binary traits across the many phenotypes of interest, which can affect the statistical power to detect associations. The...

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PMID: 29618318
DOI: 10.1186/s12859-018-2135-0
PMCID: PMC5885318

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