Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The power to detect disease associations with mitochondrial DNA haplogroups.

American journal of human genetics - 1 Apr 2006

Samuels David C, Carothers Andrew D, Horton Robin, Chinnery Patrick F

Abstract excerpt

Genetic variation of mitochondrial DNA (mtDNA) has been linked to a number of multifactorial diseases, but there is currently no tool available to predict the optimal size for these investigations. We used a simulation-based (Monte Carlo) permutation test to generate power curves for European mtDNA haplogroup studies, to derive a universal equation to enable power calculations for prospective studies across the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Mitochondrial
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Source

Open in PubMed Open full text

Identifiers

PMID: 16532401
DOI: 10.1086/502682
PMCID: PMC1424681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The power to detect disease associations with mitochondrial DNA haplogroups.PMID 16532401Read ↗

Power and SNP tagging in whole mitochondrial genome association studies.Semantic proximity Read ↗

Association testing of the mitochondrial genome using pedigree data.Semantic proximity Read ↗

A reduced number of mtSNPs saturates mitochondrial DNA haplotype diversity of worldwide population groups.Semantic proximity Read ↗

The value of molecular haplotypes in a family-based linkage study.Semantic proximity Read ↗

Detecting mtDNA Effects with an Extended Pedigree Model: An Analysis of Statistical Power and Estimation Bias.Semantic proximity Read ↗

Principal-component analysis for assessment of population stratification in mitochondrial medical genetics.Semantic proximity Read ↗

Detecting mtDNA effects with an Extended Pedigree Model: An Analysis of Statistical Power and Estimation BiasSemantic proximity Read ↗

Are molecular haplotypes worth the time and expense? A cost-effective method for applying molecular haplotypes.Semantic proximity Read ↗

Power of direct vs. indirect haplotyping in association studies.Semantic proximity Read ↗

Impact of missing genotype data on Monte-Carlo simulation based haplotype analysis.Semantic proximity Read ↗

Common European mitochondrial haplogroups in the risk for psoriasis and psoriatic arthritis.Semantic proximity Read ↗

Exact test of Hardy-Weinberg equilibrium by Markov chain Monte Carlo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.