Article
An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.
Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2001
Lu C, Shimaoka M, Ferzly M, Oxvig C, Takagi J, Springer T A
Abstract excerpt
We introduced disulfide bonds to lock the integrin alphaLbeta2 I domain in predicted open, ligand binding or closed, nonbinding conformations. Transfectants expressing alphaLbeta2 heterodimers containing locked-open but not locked-closed or wild-type I domains constitutively adhered to intercellu...
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