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Article

The role of the CPNKEKEC sequence in the beta(2) subunit I domain in regulation of integrin alpha(L)beta(2) (LFA-1).

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2002

Kamata Tetsuji, Tieu Kenneth Khiem, Tarui Takehiko, Puzon-McLaughlin Wilma, Hogg Nancy, Takada Yoshikazu

Abstract excerpt

The alpha(L) I (inserted or interactive) domain of integrin alpha(L)beta(2) undergoes conformational changes upon activation. Recent studies show that the isolated, activated alpha(L) I domain is sufficient for strong ligand binding, suggesting the beta(2) subunit to be only indirectly involved. It has been unclear whether the activity of the alpha(L) I domain is regulated by the beta(2) subunit. In this study,...

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Identifiers

PMID: 11859118
DOI: 10.4049/jimmunol.168.5.2296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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