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Article

Induction of antitumor immune response by homeostatic proliferation and CD28 signaling.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2008

Suzuki Toshihiro, Ogawa Shuhei, Tanabe Kazunari, Tahara Hideaki, Abe Ryo, Kishimoto Hidehiro

Abstract excerpt

Inducing lymphopenia before adoptive cell transfer can improve the antitumor effect of donor immune cells. It was recently reported that lymphopenic conditions can initiate the differentiation of naive T cells into effector cells. Although T cells require a specific "strong" signal via TCR as well as costimulatory signals during Ag-driven differentiation, there has been little evidence to suggest any requirement...

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Share to CD28 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18354182
DOI: 10.4049/jimmunol.180.7.4596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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