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Article

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

9 Mar 2017

Abstract excerpt

Programmed cell death-1 (PD-1)-targeted therapies enhance T cell responses and show efficacy in multiple cancers, but the role of costimulatory molecules in this T cell rescue remains elusive. Here, we demonstrate that the CD28/B7 costimulatory pathway is essential for effective PD-1 therapy during chronic viral infection. Conditional gene deletion showed a cell-intrinsic requirement of CD28 for CD8 T cell...

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Identifiers

PMID: 28280249
DOI: 10.1126/science.aaf0683

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Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependentPMID 28280249Read ↗

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