Article
Calcium regulation of myogenesis by differential calmodulin inhibition of basic helix-loop-helix transcription factors.
Molecular biology of the cell - 1 Jun 2008
Hauser Jannek, Saarikettu Juha, Grundström Thomas
Abstract excerpt
The members of the MyoD family of basic helix-loop-helix (bHLH) transcription factors are critical regulators of skeletal muscle differentiation that function as heterodimers with ubiquitously expressed E-protein bHLH transcription factors. These heterodimers must compete successfully with homodimers of E12 and other E-proteins to enable myogenesis. Here, we show that E12 mutants resistant to Ca(2+)-loaded...
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