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Article

MED12 regulates a transcriptional network of calcium-handling genes in the heart

19 Jul 2017

Abstract excerpt

The Mediator complex regulates gene transcription by linking basal transcriptional machinery with DNA-bound transcription factors. The activity of the Mediator complex is mainly controlled by a kinase submodule that is composed of 4 proteins, including MED12. Although ubiquitously expressed, Mediator subunits can differentially regulate gene expression in a tissue-specific manner. Here, we report that MED12 is...

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PMID: 28724790
DOI: 10.1172/jci.insight.91920

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