Article
DNA double-strand break repair in parental chromatin of mouse zygotes, the first cell cycle as an origin of de novo mutation.
Human molecular genetics - 1 Jul 2008
Derijck Alwin, van der Heijden Godfried, Giele Maud, Philippens Marielle, de Boer Peter
Abstract excerpt
In the human, the contribution of the sexes to the genetic load is dissimilar. Especially for point mutations, expanded simple tandem repeats and structural chromosome mutations, the contribution of the male germline is dominant. Far less is known about the male germ cell stage(s) that are most vulnerable to mutation contraction. For the understanding of de novo mutation induction in the germline, mechanistic...
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