On the parental origin of de novo mutation in man.

doi:10.1136/jmg.28.4.217

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Article

On the parental origin of de novo mutation in man.

Journal of medical genetics - 1 Apr 1991

Chandley A C

Abstract excerpt

Studies tracing parental origins of human mutations by means of cytogenetic polymorphisms and RFLPs show that most trisomics arise out of maternal errors of segregation at the first meiotic division in oocytes. Temporal disturbance of meiotic progression seems likely to underly aneuploidy product...

Topics

Animals
Humans
Male
Monosomy
Mutation
Oogenesis
Polymorphism, Restriction Fragment Length
Spermatogenesis
Trisomy

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