Article
Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed.
The Journal of clinical investigation - 1 Jul 2008
Leonard Vincent H J, Sinn Patrick L, Hodge Gregory, Miest Tanner, Devaux Patricia, Oezguen Numan, Braun Werner, McCray Paul B, McChesney Michael B, Cattaneo Roberto
Abstract excerpt
The current model of measles virus (MV) pathogenesis implies that apical infection of airway epithelial cells precedes systemic spread. An alternative model suggests that primarily infected lymphatic cells carry MV to the basolateral surface of epithelial cells, supporting MV shedding into the airway lumen and contagion. This model predicts that a mutant MV, unable to enter cells through the unidentified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.