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High-throughput amplicon scanning of the TP53 gene in breast cancer using high-resolution fluorescent melting curve analyses and automatic mutation calling.

Human mutation - 1 May 2008

Bastien Roy, Lewis Tracey B, Hawkes Jason E, Quackenbush John F, Robbins Thomas C, Palazzo Juan, Perou Charles M, Bernard Philip S

Abstract excerpt

Identifying mutations in the TP53 gene is important for cancer prognosis, predicting response to therapy, and determining genetic risk. We have developed a high-throughput scanning assay with automatic calling to detect TP53 mutations in DNA from fresh frozen (FF) and formalin-fixed paraffin-embe...

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PMID: 18348286
DOI: 10.1002/humu.20726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18348286-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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