Article
Determining the effectiveness of High Resolution Melting analysis for SNP genotyping and mutation scanning at the TP53 locus.
BMC genetics - 17 Feb 2009
Garritano Sonia, Gemignani Federica, Voegele Catherine, Nguyen-Dumont Tú, Le Calvez-Kelm Florence, De Silva Deepika, Lesueur Fabienne, Landi Stefano, Tavtigian Sean V
Abstract excerpt
BACKGROUND: Together single nucleotide substitutions and small insertion/deletion variants are the most common form of sequence variation in the human gene pool.High-resolution SNP profile and/or haplotype analyses enable the identification of modest-risk susceptibility genes to common diseases, genes that may modulate responses to pharmaceutical agents, and SNPs that can affect either their expression or...
Topics
- Cell Line, Tumor
- DNA Mutational Analysis
- DNA, Neoplasm
- Genotype
- Homozygote
- Humans
- Nucleic Acid Denaturation
- Polymorphism, Single Nucleotide
- Sensitivity and Specificity
- Tumor Suppressor Protein p53