Article
Pinpointing a selective sweep to the chimpanzee MHC class I region by comparative genomics.
Molecular ecology - 1 Apr 2008
de Groot Natasja G, Heijmans Corrine M C, de Groot Nanine, Otting Nel, de Vos-Rouweller Annemiek J M, Remarque Edmond J, Bonhomme Maxime, Doxiadis Gaby G M, Crouau-Roy Brigitte, Bontrop Ronald E
Abstract excerpt
Chimpanzees experienced a reduction of the allelic repertoire at the major histocompatibility complex (MHC) class I A and B loci, which may have been caused by a retrovirus belonging to the simian immunodeficiency virus (SIV) family. Extended MHC haplotypes were defined in a pedigreed chimpanzee colony. Comparison of genetic variation at microsatellite markers mapping inside and outside the Mhc region was carried...
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