Article
Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003
Anzai Tatsuya, Shiina Takashi, Kimura Natsuki, Yanagiya Kazuyo, Kohara Sakae, Shigenari Atsuko, Yamagata Tetsushi, Kulski Jerzy K, Naruse Taeko K, Fujimori Yoshifumi, Fukuzumi Yasuhito, Yamazaki Masaaki, Tashiro Hiroyuki, Iwamoto Chie, Umehara Yumi, Imanishi Tadashi, Meyer Alice, Ikeo Kazuho, Gojobori Takashi, Bahram Seiamak, Inoko Hidetoshi
Abstract excerpt
Despite their high degree of genomic similarity, reminiscent of their relatively recent separation from each other ( approximately 6 million years ago), the molecular basis of traits unique to humans vs. their closest relative, the chimpanzee, is largely unknown. This report describes a large-scale single-contig comparison between human and chimpanzee genomes via the sequence analysis of almost one-half of the...
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