Article
CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).
European journal of cancer (Oxford, England : 1990) - 1 Apr 2008
Jenab Mazda, McKay James D, Ferrari Pietro, Biessy Carine, Laing Stewart, Munar Gabriel Maria Capella, Sala Núria, Peña Salvador, Crusius J B A, Overvad Kim, Jensen Majken K, Olsen Anja, Tjonneland Anne, Clavel-Chapelon Françoise, Boutron-Ruault Marie-Christine, Kaaks Rudolf, Linseisen Jakob, Boeing Heiner, Bergmann Manuela M, Trichopoulou Antonia, Georgila Christina, Psaltopoulou Theodora, Mattiello Amalia, Vineis Paolo, Pala Valeria, Palli Domenico, Tumino Rosario, Numans Mattijs E, Peeters Petra H M, Bueno-de-Mesquita H Bas, Lund Eiliv, Ardanaz Eva, Sánchez Maria-Jose, Dorronsoro Miren, Sanchez Carmen Navarro, Quirós José Ramón, Hallmans Göran, Stenling Roger, Manjer Jonas, Régner Sara, Key Tim, Bingham Sheila, Khaw Kay-tee, Slimani Nadia, Rinaldi Sabina, Boffetta Paolo, Carneiro Fátima, Riboli Elio, Gonzalez Carlos
Abstract excerpt
Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. E-Cadherin is an adhesion molecule that is thought to be involved in GC. Germline mutations in the E-Cadherin gene (CDH1) have been identified in hereditary diffuse GC. Also, a promoter polymorphism at position -160 C/A has been suggested to lead to transcriptional down regulation and has been shown to affect GC risk in...
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