Article
Prediction of cancer driver mutations in protein kinases.
Cancer research - 15 Mar 2008
Torkamani Ali, Schork Nicholas J
Abstract excerpt
A large number of somatic mutations accumulate during the process of tumorigenesis. A subset of these mutations contribute to tumor progression (known as "driver" mutations) whereas the majority of these mutations are effectively neutral (known as "passenger" mutations). The ability to differentiate between drivers and passengers will be critical to the success of upcoming large-scale cancer DNA resequencing...
Topics
- Cell Line, Tumor
- Cell Transformation, Neoplastic
- Humans
- Models, Genetic
- Models, Molecular
- Mutation
- Neoplasms
- Polymorphism, Single Nucleotide
- Protein Kinases