Article
Cancer driver mutations in protein kinase genes.
Cancer letters - 28 Aug 2009
Torkamani Ali, Verkhivker Gennady, Schork Nicholas J
Abstract excerpt
Recent studies investigating the genetic determinants of cancer suggest that some of the genetic alterations contributing to tumorigenesis may be inherited, but the vast majority is somatically acquired during the transition of a normal cell to a cancer cell. A systematic understanding of the genetic and molecular determinants of cancers has already begun to have a transformative effect on the study and treatment...
Topics
- Animals
- Cell Transformation, Neoplastic
- Humans
- Mutation
- Neoplasms
- Protein Kinases